Citric Acid Cycle Intermediates in Cardioprotection
نویسندگان
چکیده
منابع مشابه
Citric acid cycle intermediates in cardioprotection.
Over the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we will review the proximity of the metabolic approach to clinical practice. Specifically, we will focus on how the citric acid cycle is involved i...
متن کاملMitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates.
Kidney proximal tubule cells developed severe energy deficits during hypoxia/reoxygenation not attributable to cellular disruption, lack of purine precursors, the mitochondrial permeability transition, or loss of cytochrome c. Reoxygenated cells showed decreased respiration with complex I substrates, but minimal or no impairment with electron donors at complexes II and IV. This was accompanied ...
متن کاملDifferential effects of heptanoate and hexanoate on myocardial citric acid cycle intermediates following ischemia-reperfusion.
In the normal heart, there is loss of citric acid cycle (CAC) intermediates that is matched by the entry of intermediates from outside the cycle, a process termed anaplerosis. Previous in vitro studies suggest that supplementation with anaplerotic substrates improves cardiac function during myocardial ischemia and/or reperfusion. The present investigation assessed whether treatment with the ana...
متن کاملRegulation of citric acid cycle by calcium.
The relationship of extramitochondrial Ca2+ to intramitochondrial Ca2+ and the influence of intramitochondrial free Ca2+ concentrations on various steps of the citric acid cycle were evaluated. Ca2+ was measured using the Ca2+ sensitive fluorescent dye fura-2 trapped inside the rat heart mitochondria. The rate of utilization of specific substrates and the rate of accumulation of citric acid cyc...
متن کاملMitochondrial-Cytosolic Interactions in Perfused Rat Heart ROLE OF COUPLED TRAKSAMINATION IN REPLETION OF CITRIC ACID CYCLE INTERMEDIATES*
The kinetics of changes in the tissue content of citric acid cycle intermediates and free amino acids have been investigated in isolated perfused hearts during the transition from substrate-free perfusion to perfusion with medium containing 5 mM glucose and 5 s 10m3 units of insulin per ml. Glycolytic flux increased within 1 min to about 300 pmoles of glucose equivalents per g (dry weight) per ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation: Cardiovascular Genetics
سال: 2014
ISSN: 1942-325X,1942-3268
DOI: 10.1161/circgenetics.114.000220